Review Questions
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1.
Which of the following is a likely cause of duodenal ulceration in patients who are Helicobacter pylori negative?
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a.
Bordetella pertussis infection
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b.
Zollinger-Ellison syndrome
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c.
Pheochromocytoma
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d.
Mercury poisoning
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e.
None of the above
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2.
An 80-year-old woman with degenerative joint disease involving her fingers presents with a gastric ulcer with smooth edges. She denies being prescribed nonsteroidal anti-inflammatory drugs (NSAIDs), and biopsies and serology for H. pylori are negative. Which of the following is the most likely cause of her ulcer?
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a.
Gastric rheumatoid nodules
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b.
Systemic lupus erythematosus
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c.
Over-the-counter medications containing NSAIDs
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d.
Ankylosing spondylitis
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e.
Surreptitious laxative abuse
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3.
Which of the following is the major factor contributing to current changes in the incidence of peptic ulcer disease in developed countries?
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a.
The rise in H. pylori−associated gastric ulcers
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b.
The fall in NSAID-associated duodenal ulcers
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c.
The rise in NSAID-related gastric ulcers
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d.
The rise in NSAID-related duodenal ulcers
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e.
The rise in intensive care unit (ICU)-related stress ulcers
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4.
Which of the following is correct about peptic ulcer disease?
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a.
Risk is greatest in females.
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b.
The highest relative risk is in persons younger than 20 years.
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c.
Treatment of autoimmune diseases with biologic agents (e.g., anti−tumor necrosis factor [TNF]-α agents) has increased risk.
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d.
Most deaths are due to gastric cancer.
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e.
Smoking increases risk.
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5.
Which of the following involves an increased risk for peptic ulcer disease?
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a.
Scleroderma
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b.
Pernicious anemia
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c.
Celiac disease
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d.
Systemic mastocytosis
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e.
Cryptococcosis
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6.
The effect of H. pylori eradication therapy always needs to be assessed in patients with which of the following?
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a.
A bleeding peptic ulcer
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b.
Reflux esophagitis
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c.
Nonulcer dyspepsia
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d.
Uncomplicated peptic ulcer
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e.
Chronic active gastritis
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7.
Which of the following statements is false in patients with peptic ulcer bleeding?
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a.
Endoscopic treatment is the mainstay of therapy.
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b.
Preemptive proton pump inhibitor (PPI) therapy reduces the need for endoscopic treatment.
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c.
High-dose continuous intravenous PPI treatment reduces the risk for rebleeding.
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d.
Patients with a low Blatchford score usually do not require intervention.
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e.
Recurrent bleeding requires surgery.
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